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目的探讨血清降钙素原(PCT)检测对判断糖皮质激素治疗个体外周血白细胞升高是由于糖皮质激素作用还是发生细菌感染的意义。方法采用双抗夹心免疫荧光法检测血清PCT。结果抗生素治疗72h前,PCT为(6.08±4.39)×106μg/L,治疗后PCT为(0.52±0.24)×106μg/L,治疗前后对比,PCT明显下降,差异有统计学意义(t=30.848 5,P<0.01)。结论 PCT可以作为鉴定糖皮质激素治疗个体感染性或非感染性白细胞升高的重要辅助指标,可以早期发现感染,连续监测血清PCT水平可以指导抗生素用药并且能判断疗效和预后。
Objective To investigate the significance of serum procalcitonin (PCT) test to determine whether glucocorticoid treatment or bacterial infection is caused by the increase of peripheral white blood cells in patients treated with glucocorticoid. Methods Serum PCT was detected by double antibody sandwich immunoassay. Results The PCT was (6.08 ± 4.39) × 106μg / L before treatment and the PCT was (0.52 ± 0.24) × 106μg / L before and 72 hours after antibiotics treatment. The PCT decreased significantly before and after treatment, with a significant difference (t = 30.848 5 , P <0.01). Conclusions PCT can be used as an important auxiliary index to identify glucocorticoid treatment of infectious or non-infectious leukocytosis in patients with early detection of infection, continuous monitoring of serum PCT levels can guide the use of antibiotics and can determine the efficacy and prognosis.