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为研究中药抗旱孕的作用机理,采用雌性金黄地鼠于受精后第4天灌服中药,每天2次,连续3天。结果:①抗早孕效果明显,孕鼠子宫串珠样隆起萎缩,消失;②石蜡切片观察子宫内膜上皮细胞排列紊乱,固有层出血;③超薄切片电镜观察上皮细胞纤毛消失,线粒体和核糖体增多;④亲和细胞化学技术观察,ConA、PNA、UEA等凝集素受体增多。结论:灌服中药使子宫内膜发生形态学改变,影响了胚胎生存发育的环境,出现明显的抗早孕作用。有意义的是在停药后第10天左右,实验动物全部恢复动情周期交配生仔,表明中药抗早孕作用是可逆的。
In order to study the mechanism of anti-drought of traditional Chinese medicine, female golden hamsters were given Chinese medicine 4 days after fertilization twice a day for 3 consecutive days. RESULTS: 1 The anti-pregnancy effect was obvious. The uterus beaded uplift of pregnant mice was atrophied and disappeared. (2) Paraffin sections were observed and the endometrial epithelial cells were disordered and the inherent layer was hemorrhagic; (3) Ultra-thin section electron microscopy revealed that epithelial cells lost cilia and mitochondria and ribosomes increased. ;4 Affinity cell chemistry observations, ConA, PNA, UEA and other lectin receptors increased. CONCLUSION: The morphological changes of the endometrium after oral administration of traditional Chinese medicine impairs the survival and development environment of the embryos, and has obvious anti-pregnancy effects. It is significant that around the 10th day after discontinuation of treatment, all experimental animals returned to estrus for mating, indicating that the anti-early pregnancy effect of Chinese herbs is reversible.