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目的分析血清β_2-微球蛋白在糖尿病肾病中的诊断价值。方法选取景德镇市疾病预防控制中心2014年1月—2015年1月收治的糖尿病肾病患者35例为A组,未合并肾病的糖尿病患者35例为B组,另选取健康体检人员35例为对照组,比较3组受试者血清β_2-微球蛋白水平及血清β_2-微球蛋白异常率。结果 3组受试者血清β_2-微球蛋白水平、血清β_2-微球蛋白水平异常率比较,差异有统计学意义(P<0.05);其中A组患者血清β_2-微球蛋白水平、血清β_2-微球蛋白水平异常率高于B组和对照组(P<0.05);B组患者血清β_2-微球蛋白水平、血清β_2-微球蛋白水平异常率高于对照组(P<0.05)。结论血清β_2-微球蛋白水平可以作为糖尿病肾病的早期诊断的敏感指标。
Objective To analyze the diagnostic value of serum β_2-microglobulin in diabetic nephropathy. Methods 35 cases of diabetic nephropathy admitted from January 2014 to January 2015 in Jingdezhen Municipal Center for Disease Control and Prevention were selected as group A, 35 cases of non-nephropathy diabetic patients as group B and 35 cases of healthy physical examination as control group The levels of serum β_2-microglobulin and serum β_2-microglobulin in the three groups were compared. Results The serum β_2-microglobulin levels and serum β_2-microglobulin levels in the three groups were significantly different (P <0.05). The serum levels of β_2-microglobulin, serum β_2 (P <0.05). The abnormal level of serum β_2-microglobulin and β_2-microglobulin in group B were higher than those in control group (P <0.05). Conclusion Serum β_2-microglobulin level can be used as a sensitive indicator of early diagnosis of diabetic nephropathy.