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结扎家兔肠系膜上动脉1小时后,用颈动脉血流经灌流泵再灌注SMA,比较不同的再灌注压对缺血小肠的影响。结果表明120mmHg的高压再灌注导致最严重的组织损伤,低压(60mmHg)和逐渐升压(60～175～90mmHg)较中压(90mmHg)灌注引起的组织损伤轻。进一步实验,在家兔晚期失血性休克模型上发现,迅速提高灌注压恢复灌流比逐步提高灌流压引起的组织损伤更严重,动物死亡率高。说明再灌注损伤与再灌压有密切关系。在休克治疗中,如何合理地恢复组织器官的灌流,值得进一步探讨。
One hour after ligation of the superior mesenteric artery in rabbits, SMA was reperfused with carotid artery perfusion pump and the effect of different reperfusion pressure on ischemic small intestine was compared. The results showed that 120 mmHg of high pressure reperfusion resulted in the most severe tissue damage, which was less severe than low pressure (60 mmHg) and gradual ascending (60-175-90 mmHg) over medium pressure (90 mmHg) perfusion. Further experiments showed that in the model of advanced hemorrhagic shock in rabbits, it is found that the rapid recovery of perfusion pressure is more serious than the gradual increase of perfusion pressure, and the animal mortality rate is high. Reperfusion injury and reperfusion have a close relationship. In the treatment of shock, how to reasonably restore the perfusion of tissues and organs, it is worth further exploration.