论文部分内容阅读
肿瘤坏死因子-α(TNF-α)是一种具有广泛生物学功能的细胞因子,参与机体免疫应答和炎症反应。脑缺血再灌注后脑内TNF-α的表达增加,在再灌注损伤病理过程中TNF-α具有损伤与修复双重作用。其作用机制与致炎、促凝血机制、血脑屏障破坏、诱导缺血耐受及神经生长因子生成等有关。
Tumor necrosis factor-α (TNF-α) is a cytokine with a wide range of biological functions, involved in the body’s immune response and inflammatory response. After cerebral ischemia and reperfusion, the expression of TNF-α in the brain increased. TNF-α had the dual role of injury and repair in the pathological process of reperfusion injury. Its mechanism of action and pro-inflammatory, procoagulant mechanism, the destruction of the blood-brain barrier, induced ischemia tolerance and the generation of nerve growth factor and so on.