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目的比较芬太尼贴剂联合盐酸吗啡缓释片治疗癌痛的临床疗效。方法将符合病例入选标准的80例癌痛患者随机分为观察组、对照组,每组40例。2组均给予盐酸吗啡缓释片,观察组给予芬太尼贴剂,每3日更换1次。2组均以服药10d为1个疗程,治疗2个疗程后观察2组疼痛缓解程度、生活质量的改善情况及头晕、嗜睡、恶心、呕吐、便秘、排尿困难等不良反应的发生情况。结果 CR率观察组为57.50%,对照组为40.00%,2组相比差异有统计学意义(P﹤0.05)。(CR+PR+MR)率观察组为95.00%,对照组为75.00%,2组相比较差异有统计学意义(P﹤0.05)。食欲、睡眠、日常活动、精神状态、情绪、与人交往、生活兴趣等方面2组治疗前后组内相比差异有统计学意义(P﹤0.05);2组治疗组间相比差异有统计学意义(P﹤0.05)。结论芬太尼贴剂联合盐酸吗啡缓释片治疗癌痛临床疗效显著,不良反应小。
Objective To compare the clinical efficacy of fentanyl and morphine hydrochloride in the treatment of cancer pain. Methods Eighty patients with cancer pain who met the criteria of the case were randomly divided into observation group and control group, 40 cases in each group. Both groups were given morphine hydrochloride sustained-release tablets, the observation group was given fentanyl patch every 3 days. The two groups were taking medication for 10d as a course of treatment. After 2 courses of treatment, the degree of pain relief, quality of life improvement, dizziness, drowsiness, nausea, vomiting, constipation, dysuria and other adverse reactions were observed. Results The CR rate was 57.50% in the observation group and 40.00% in the control group. There was significant difference between the two groups (P <0.05). (CR + PR + MR) rate was 95.00% in the observation group and 75.00% in the control group. There was significant difference between the two groups (P <0.05). There was significant difference between the two groups before and after treatment (P <0.05), such as appetite, sleep, daily activities, mental state, emotion, interaction with people and interest in life. There was significant difference between the two groups Significance (P <0.05). Conclusion Fentanyl patch combined with morphine hydrochloride sustained-release tablets for the treatment of cancer pain has a significant clinical effect and small adverse reactions.