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目的比较微小剂量平阳霉素(PYM)和常规剂量平阳霉素瘤内注射治疗婴幼儿口腔颌面部血管瘤的疗效。方法收集两组婴幼儿血管瘤患者,一组52例采用微小剂量PYM(浓度为0.2mg.mL-1)瘤内注射治疗,另一组45例采用常规剂量PYM(浓度为1mg.mL-1)瘤内注射治疗,两组均间隔2周或更长时间(视肿胀消退程度)重复注射,2~10次治疗结束。结果3、6、9个月随访观察,两组间的疗效差异无统计学意义(Z=-1.293,P=0.196)。两组的不良反应差别也无统计学意义。结论微小剂量PYM治疗婴幼儿口腔颌面部软组织血管瘤能获得常规剂量的临床疗效,值得临床推广使用。
Objective To compare the efficacy of micro-dose pingyangmycin (PYM) and conventional injection of pingyangmycin in the treatment of oral and maxillofacial hemangiomas in infants. Methods Two groups of infantile hemangiomas were collected. One group of 52 patients received intratumoral injection of PYM at a dose of 0.2 mg.mL-1, and the other 45 patients received conventional intraperitoneal injection of PYM at a concentration of 1 mg.mL-1 ) Intratumoral injection therapy, two groups were at intervals of 2 weeks or longer (depending on the degree of swelling subsided) repeated injections, 2 to 10 times the end of treatment. Results After 3, 6 and 9 months of follow-up, there was no significant difference in efficacy between the two groups (Z = -1.293, P = 0.196). Adverse reactions between the two groups also showed no significant difference. Conclusion The small dose of PYM in the treatment of infantile oral and maxillofacial soft tissue hemangiomas can get the routine dose of clinical efficacy, worthy of clinical promotion.