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病原微生物效应蛋白引发的免疫(effector triggered immunity ETI)是植物天然免疫的重要组成部分,在ETI反应中,植物通过胞内免疫受体特异性地识别病原物分泌的效应蛋白进而激活下游的抗性反应,但免疫受体的活性调控机理仍不清楚。拟南芥的抗性蛋白RPM1是重要的细胞内免疫受体,RPM1特异性地介导对效应蛋白Avr B的识别,这种识别是通过对RPM1-互作蛋白RIN4的Thr166磷酸化介导的。目前的模型认为,该位点磷酸化直接被RPM1所识别,触发免
The effector triggered immunity (ETI) is an important part of plant innate immunity. In the ETI reaction, plants specifically recognize the effector proteins secreted by pathogens through the intracellular immunoreceptor to activate the downstream resistance Reaction, but the regulation of the activity of immune receptors remains unclear. The Arabidopsis thaliana resistance protein RPM1 is an important intracellular immune receptor and RPM1 specifically mediates the recognition of the effector protein Avr B through the Thr166 phosphorylation of RPM1-interacting protein RIN4 . The current model suggests that phosphorylation at this site is directly recognized by RPM1 and triggered