10岁女孩,发热一周,伴头痛,曾服复方新诺明日3片共4天,后肌注庆大霉素3天效差,以“发热待查”入院。体温38℃,咽充血,扁桃体肿大,心肺无殊。予氨苄青霉素静点、口服新诺明日2片治疗,次日发现浓茶水样尿,面色黄,巩膜黄染,下肢见针尖样出血点,肝肋下2cm,脾肋下1cm;尿蛋白卅,红细胞少许,住院第六天血红蛋白70g/L,网织红5%,血小板54×10~9/L,未发现球型红细胞,血冷凝试验、变性珠蛋白小体生成试验及Coomb(?)s 试验,Ham’s 10-year-old girl, fever for a week, with headache, had served three days of cotrimoxazole 3 days a total of 4 days after the intramuscular injection of gentamicin 3 days poor, “fever pending” admission. Body temperature 38 ℃, pharyngeal congestion, tonsil enlargement, no special cardiopulmonary. To ampicillin intravenous injection, tomorrow Minocycle 2 treatment, the next day found thick tea water samples urine, yellow, sclera yellow dye, see the tip of the lower extremity bleeding point, liver ribs 2cm, 1cm spleen ribs; urinary protein 卅, A small amount of red blood cells, hemoglobin 70g / L on the sixth day of hospitalization, reticulocyte red 5%, platelets 54 × 10 ~ 9 / L, no globular erythrocytes, blood condensation test, denatured globin body formation test and Coomb s test, Ham’s