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目的 探讨一氧化氮 (NO)和内皮素 1(ET 1)在支气管哮喘发病中的作用。方法 采用放射免疫法和比色法测定 4 2例支气管哮喘患者和 3 0例健康对照者血浆ET 1和硝酸根离子 亚硝酸根离子 (NO-2 NO-3 )含量。结果 轻度支气管哮喘组 :血浆NO-2 NO-3 含量明显高于健康对照组 ;ET 1含量与健康对照组相比无明显差异。中度支气管哮喘组 :血浆NO-2 NO-3 和ET 1含量均显著高于健康对照组 (P <0 0 5 )。重度支气管哮喘组 :血浆NO-2 NO-3和ET 1亦显著高于健康对照组 (P <0 0 1)。结论 ET 1和NO参与支气管哮喘发病的病理生理过程 ,血浆ET 1和NO-2 NO-3 水平可作为判定支气管哮喘病情的重要指标。
Objective To investigate the role of nitric oxide (NO) and endothelin 1 (ET 1) in the pathogenesis of bronchial asthma. Methods The levels of plasma ET 1 and nitrate ion nitrite (NO-2 NO-3) in 42 patients with bronchial asthma and 30 healthy controls were measured by radioimmunoassay and colorimetry. Results In mild bronchial asthma group, NO-2 NO-3 content in plasma was significantly higher than that in healthy controls; ET 1 content was not significantly different from healthy controls. Moderate bronchial asthma group: plasma NO-2 NO-3 and ET 1 levels were significantly higher than the healthy control group (P <0 05). In severe bronchial asthma group, NO-2 and ET-1 in plasma were also significantly higher than those in healthy controls (P <0.01). Conclusions ET 1 and NO are involved in the pathophysiological process of bronchial asthma. The levels of ET 1 and NO-2 in plasma may be used as important indicators in judging bronchial asthma.