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目的探讨呼和浩特市地区发热伴出疹症性疾病(RFIs)的病原谱构成。方法 2009～2011年,采用酶联免疫吸附试验(ELISA)对RFIs患者急性期血清标本进行麻疹、风疹、水痘、肠道病毒、小DNA病毒B19、登革热IgM抗体检测,采用Real-time PCR方法对咽拭子标本检测病毒核酸。结果对31份血清进行IgM抗体检测,其中3份为阳性结果,检出率为9.68%。对294份咽拭子样本进行核酸检测,其中117份为阳性,阳性率为39.80%。共104份为肠道病毒阳性,占所有阳性样本的86.67%,18份为水痘带状疱疹病毒,3份麻疹病毒,1份小DNA病毒B19,其中6份为混合感染。麻疹阳性病例均无免疫史,水痘阳性病例94.44%无免疫史。结论 2009～2011年,呼和浩特地区RFIs病原以肠道病毒为主,其次是水痘病毒。加速肠道病毒疫苗的研制,积极推行水痘、麻疹等疫苗接种是控制RFIs发病的主要措施。
Objective To investigate the pathogenic spectrum of fever with rash disease (RFIs) in Hohhot. Methods From 2009 to 2011, measles, rubella, chickenpox, enterovirus, small DNA virus B19 and dengue IgM were detected by enzyme-linked immunosorbent assay (ELISA) in serum of patients with RFIs. Real-time PCR Throat swab specimens were tested for viral nucleic acid. Results 31 serum samples were tested for IgM antibody, of which 3 were positive and the detection rate was 9.68%. 294 samples of throat swabs were tested for nucleic acid, of which 117 were positive and the positive rate was 39.80%. A total of 104 were positive for enterovirus, accounting for 86.67% of all positive samples, 18 were varicella zoster virus, 3 measles virus and 1 small DNA virus B19, of which 6 were mixed infections. Measles-positive cases were no history of immunization, varicella-positive cases 94.44% no history of immunity. Conclusion From 2009 to 2011, the pathogen of RFIs in Hohhot was mainly enterovirus, followed by varicella virus. Accelerate the development of enterovirus vaccine, and actively promote the vaccination of chickenpox, measles and other vaccines are the main measures to control the incidence of RFIs.