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目的:探讨地西他滨4d疗程方案治疗老年急性白血病的疗效及安全性。方法:应用地西他滨30mg/m2 4d疗程方案治疗4例老年急性髓系白血病,并评价其疗效和不良反应。结果:2例患者应用地西他滨4疗程后达完全缓解,1例在3疗程后获部分缓解,1例1疗程后因多器官功能衰竭死亡。4例患者治疗过程中均出现较明显的粒细胞和血小板减少。结论:地西他滨是治疗老年急性髓系白血病的有效选择,疗效较好,不良反应可以耐受。4d方案在疗效和耐受性上与3d和5d方案相比,无明显差别,应用方便。
Objective: To investigate the efficacy and safety of decitabine 4 days regimen in the treatment of senile acute leukemia. Methods: Decitabine 30mg / m2 4d course of treatment of 4 cases of elderly acute myeloid leukemia and evaluate the efficacy and adverse reactions. Results: Two patients achieved complete remission after 4 courses of treatment with decitabine. One case was partially relieved after 3 courses and one case died of multiple organ failure after one course of treatment. 4 patients were treated during the more obvious granulocytes and thrombocytopenia. Conclusion: Decitabine is an effective treatment for senile acute myeloid leukemia with good curative effect and adverse reactions can be tolerated. 4d program efficacy and tolerability compared with the 3d and 5d programs, no significant difference, easy to use.