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目的:观察阿米卡星相同日剂量2种不同给药方法对药物经济学的影响。方法:66例细菌感染患者采用阿米卡星0.4 g,ivd qd,随机分为A、B组,A组,4～8 mg·min~(-1),B组按经验,未规定单位时间给药量。结果:A组和B组药物血药浓度≤15.1μg·ml~(-1)分别有4例和22例;临床有效率为91.4%(32/35)和38.7%(12/31),成本-效果比(C/E)A组为4079,B组为9755。结论:A组比B组(按经验习惯性给药)治疗效果好,更经济。
Objective: To observe the influence of two different administration methods of amikacin on the pharmacoeconomics at the same daily dose. Methods: 66 patients with bacterial infection were treated with amikacin 0.4 g, ivd qd and randomly divided into group A and group B, group A, 4 to 8 mg · min -1, group B according to experience without stipulation of unit time Dose. Results: The blood concentration of group A and group B were 4 and 22, respectively. The clinical effective rates were 91.4% (32/35) and 38.7% (12/31), respectively. The costs - Effective ratio (C / E) A group was 4079, B group was 9755. Conclusion: A group than B group (according to empirical habitual administration) treatment effect is good, more economical.