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目的检测常见恶性肿瘤患者的血浆同型半胱氨酸(Hcy)和血清叶酸水平,并探讨其与细胞癌变的关系。方法对142例常见恶性肿瘤患者(包括食管癌20例,胃癌31例,结直肠癌32例,肺癌22例,乳腺癌23例,卵巢癌14例,采用高效液相色谱荧光法检测血浆Hcy,放射免疫法测定血清叶酸。对照组为50名健康体检者。结果各组恶性肿瘤患者与正常对照组之间血浆Hcy血清叶酸水平的差异均有统计学意义(P<0.05或<0.001)。结论常见恶性肿瘤患者血清叶酸水平下降而血浆Hcy水平升高,其原因值得进一步研究。
Objective To detect the levels of plasma homocysteine (Hcy) and serum folate in patients with common malignant tumors and to explore its relationship with carcinogenesis. Methods Totally 142 patients with malignant tumor (including 20 cases of esophageal cancer, 31 cases of gastric cancer, 32 cases of colorectal cancer, 22 cases of lung cancer, 23 cases of breast cancer and 14 cases of ovarian cancer were detected by high performance liquid chromatography (HPLC) Serum folic acid was measured by radioimmunoassay and the control group was 50 healthy subjects.Results There was significant difference in plasma Hcy serum folate levels between malignant tumor patients and normal control group (P <0.05 or <0.001) .Conclusion Serum folic acid levels in patients with common malignancy decreased plasma Hcy levels, the reason worth further study.