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目的探究血清胱抑素C和尿mALB及尿GGT值与2型糖尿病的关系以改良临床诊断。方法根据患者尿液中的白蛋白含量的多少将在本院确诊治疗的2型糖尿病肾病患者163例分为尿白蛋白正常组,尿白蛋白微过量组组和尿白蛋白大量过量组并以健康体检人群50例为对照组。血清胱抑素C(CysC)和尿微量白蛋白(mALB)和尿GGT含量采用免疫比浊法检测。结果正常组和A组血CysC和尿mALB值差异不明显,说明无肾功能病变的2型糖尿病患者的血CysC和尿mALB及尿GGT值均属与正常范围内差异无统计学意义(P>0.05)。正常组和B组C组血CysC和尿mALB及尿GGT值差异非常明显各组差异有统计学意义(P<0.05)。结论血清Cysc和尿mALB及尿GGT的检测有助于判断2型糖尿病早期肾功能损害帮助医生及时发现病情及时处理。
Objective To investigate the relationship between serum cystatin C, urinary mALB, urinary GGT and type 2 diabetes in order to improve clinical diagnosis. Methods According to the amount of albumin in patients’ urine, 163 patients with type 2 diabetic nephropathy diagnosed and treated in our hospital were divided into normal albuminuria group, microalbuminuria group and urinary albumin excess group 50 healthy people in the control group. Serum levels of cystatin C (CysC), urinary microalbumin (MALB) and urinary GGT were measured by immunoturbidimetry. Results There was no significant difference in CysC and urinary mALB between normal group and A group, which indicated that there was no significant difference in CysC, urinary mALB and urinary GGT between type 2 diabetes mellitus without renal function and normal range (P> 0.05). The differences of CysC, urine mALB and urinary GGT between normal group and B group C group were significant (P <0.05). Conclusion The detection of serum Cysc, urinary mALB and urinary GGT can help to determine the early renal dysfunction in type 2 diabetic patients and help doctors find out the condition in time.