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１引言 糖尿病神经病变是糖尿病常见的慢性并发症和主要的致残因素之一，其病因主要是长期严重的高血糖及由此而导致的代谢障碍、微循环异常和自身免疫紊乱［１］。糖尿病神经病变仍然是临床治疗学的难题，目前尚无确实有效的治疗方法。前列地尔具有扩张末梢血管、增加血流量以
1 Introduction Diabetic neuropathies are one of the most common chronic complications and major causes of disability in diabetes mellitus. The main causes are long-term and severe hyperglycemia, resulting in metabolic disorders, microcirculation, and autoimmune disorders [1]. Diabetic neuropathy is still a difficult problem in clinical therapeutics, so there is no effective treatment. Alprostadil has the expansion of peripheral blood vessels to increase blood flow to