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目的观察氯吡格雷联合依诺肝素钠治疗不稳定型心绞痛的临床疗效及对冠心病重要危险因子-血脂的影响。方法将108例不稳定型心绞痛患者随机分为治疗组58例和对照组50例,对照组给予依诺肝素钠加阿司匹林,治疗组在对照组治疗基础上加用氯吡格雷。所有病例均于治疗前后分别观察心绞痛发作次数、持续时间和血脂水平等指标。结果治疗后,治疗组总有效率(89.7%)明显高于对照组(72%),两组差异具有统计学意义(P<0.05);两组心绞痛平均发作次数、平均持续时间及治疗组血脂各项指标均较治疗前明显改善,差异有统计学意义(P<0.01);治疗后两组比较,治疗组改善程度优于对照组,差异亦有统计学意义(P<0.01)。结论氯吡格雷联合依诺肝素钠治疗不稳定型心绞痛疗效确切,可显著改善患者血脂水平。
Objective To observe the clinical efficacy of clopidogrel in combination with enoxaparin sodium in the treatment of unstable angina pectoris and its effect on blood lipid, an important risk factor of coronary heart disease. Methods A total of 108 patients with unstable angina pectoris were randomly divided into treatment group (58 cases) and control group (50 cases). The control group was given enoxaparin sodium plus aspirin. The treatment group was given clopidogrel on the basis of the control group. All cases were observed before and after treatment angina pectoris frequency, duration and lipid levels and other indicators. Results After treatment, the total effective rate (89.7%) in the treatment group was significantly higher than that in the control group (72%), the difference between the two groups was statistically significant (P <0.05); the mean number of seizures, The indexes were significantly improved compared with that before treatment (P <0.01). After treatment, the improvement in treatment group was better than that in control group (P <0.01). Conclusion Clopidogrel combined with enoxaparin sodium is effective in treating unstable angina pectoris and can significantly improve the level of blood lipids in patients.