论文部分内容阅读
目的运用DTI直方图分析,研究脊髓型多发性硬化(SMS)患者是否存在脑灰质异常及脑灰质DTI指标与临床评分的相关性。方法对25例SMS患者和35例正常志愿者行常规MRI和DTI检查,分割提取脑灰质后,研究SMS患者脑灰质平均弥散率(MD)和分数各向异性(FA)直方图的异常变化。结果OSMS患者脑灰质体积明显小于正常志愿者(P<0.001)。OSMS患者脑灰质MD和FA直方图指标与正常志愿者间存在显著差异(P<0.01)。在OSMS患者,所有脑灰质DTI直方图指标与扩展残疾状态评分(EDSS)均无相关性,但锥体束和感觉系统(PSS)评分与脑灰质平均MD(r=0.54,P=0.005)和MD直方图峰高(r=-0.41,P=0.04)中度相关。结论OSMS患者脑灰质存在明显萎缩和弥散异常,这可能与继发于脊髓病变的逆行性脑灰质神经元变性有关。
Objective To investigate the correlation between gray matter abnormalities and gray matter index (DTI) in clinical patients with spinal cord multiple sclerosis (SMS) using DTI histogram analysis. Methods Twenty-five patients with SMS and 35 normal volunteers underwent routine MRI and DTI examinations. The abnormal changes of gray matter average diffusion rate (MD) and fractional anisotropy (FA) histograms were studied after segmentation and extraction of gray matter. Results The volume of gray matter in OSMS patients was significantly less than that in normal volunteers (P <0.001). OSMS patients with gray matter MD and FA histogram indicators and normal volunteers there is a significant difference (P <0.01). In OSMS, all gray matter DTI histograms did not correlate with extended disability status scores (EDSS), but PSS score was significantly associated with mean gray matter (r = 0.54, P = 0.005) and MD histogram peak height (r = -0.41, P = 0.04) moderate correlation. Conclusion There is obvious atrophy and diffuse abnormalities of gray matter in OSMS patients, which may be related to the degeneration of retrograde cerebral gray matter neurons secondary to spinal cord lesions.