论文部分内容阅读
目的探讨原发性高血压(EH)患者左心室肥厚与尿微量白蛋白(MAU)、血浆血管紧张素Ⅱ(AngⅡ)及氨基末端脑钠肽前体(NT-proBNP)的关系。方法 EH患者180例分为高血压伴左心室肥厚组(LVH组,n=90)和高血压不伴左心室肥厚组(NLVH组,n=90),健康对照组90例。超声测定各组舒张末期左心室内径(LVDd)、舒张末期室间隔厚度(IVST)、左心室后壁厚度(PWT);采取放射免疫法检测血浆AngⅡ、MAU浓度,计算24h尿白蛋白排泄量(UAE),电化学发光免疫技术检测NT-proBNP浓度,比较3组各指标的差异。结果 LVH组的UAE、AngⅡ及NT-proBNP均高于NLVH组及对照组(均P<0.05),LVH患者UAE、AngⅡ及NT-proBNP与左室质量指数(LVMI)呈正相关。结论合并LVH的EH患者UAE、血浆AngⅡ及NT-proBNP均增高。EH患者LVH与UAE、血浆AngⅡ及NT-proBNP水平相关。
Objective To investigate the relationship between left ventricular hypertrophy (LVH) and urinary microalbumin (MAU), plasma angiotensin Ⅱ (Ang Ⅱ) and NT-proBNP in patients with essential hypertension (EH). Methods 180 cases of EH were divided into hypertensive group with left ventricular hypertrophy (LVH group, n = 90) and hypertensive group without left ventricular hypertrophy (NLVH group, n = 90), 90 healthy controls. The left ventricular end diastolic diameter (LVDd), end diastolic septum thickness (IVST) and left ventricular posterior wall thickness (PWT) in each group were measured by ultrasound. The levels of plasma AngⅡ and MAU were measured by radioimmunoassay and the urinary albumin excretion UAE), electrochemiluminescence immunoassay NT-proBNP concentrations were compared, the differences between the three groups of indicators were compared. Results The levels of UAE, AngⅡand NT-proBNP in LVH group were significantly higher than those in NLVH group and control group (all P <0.05). There was a positive correlation between UAE, AngⅡand NT-proBNP and LVMI in patients with LVH. Conclusion The levels of UAE, plasma AngⅡ and NT-proBNP in EH patients with LVH were significantly higher than those in control group. EH patients with LVH and UAE, plasma Ang Ⅱ and NT-proBNP levels.