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目的了解浙江省湖州市中心医院常见葡萄球菌感染现状及耐药特点。方法将2003-01~2003-12湖州市中心医院采集的360株葡萄球菌采用常规方法分离,用Vitek-32全自动微生物分析仪进行菌种鉴定及药敏试验。结果分离到金黄色葡萄球菌205株,表皮葡萄球菌95株,溶血性葡萄球菌60株。其中耐甲氧西林葡萄球菌共247株,包括耐甲氧西林金黄色葡萄球菌131株(36.4%),耐甲氧西林表皮葡萄球菌72株(20.0%),耐甲氧西林溶血性葡萄球菌44株(12.2%)。耐甲氧西林金黄色葡萄球菌、表皮葡萄球菌和溶血性葡萄球菌均呈多重耐药特征,未发现耐万古霉素、替考拉宁的葡萄球菌。结论耐甲氧西林葡萄球菌检出率呈明显上升趋势,合理使用抗生素,尤其万古霉素的使用,已成为当务之急。
Objective To understand the status and drug resistance of common staphylococcal infections in Huzhou Central Hospital of Zhejiang Province. Methods 360 Staphylococcus aureus collected from Huzhou Central Hospital from January 2003 to December 2003 were separated by routine methods and the strain identification and drug susceptibility test were carried out by Vitek-32 automatic microbial analyzer. Results 205 Staphylococcus aureus, 95 Staphylococcus epidermidis and 60 Staphylococcus haemolyticus were isolated. Among them, 247 strains of methicillin-resistant Staphylococcus aureus were found, including 131 (36.4%) of methicillin-resistant Staphylococcus aureus, 72 (20.0%) of methicillin-resistant Staphylococcus epidermidis, methicillin-resistant Staphylococcus aureus Strain (12.2%). Methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis and Staphylococcus haemolyticus showed multi-drug resistance characteristics, and vancomycin-resistant and teicoplanin-resistant Staphylococcus were not found. Conclusion The detection rate of methicillin-resistant Staphylococcus aureus showed a clear upward trend. The rational use of antibiotics, especially vancomycin, has become a top priority.