论文部分内容阅读
目的 研究纳洛酮对血管性痴呆大鼠学习与记忆能力的影响。方法 采用结扎大鼠双侧颈总动脉方法 ,制备血管性痴呆模型后随机分为模型组和治疗组 ,另设假手术组。治疗组大鼠连续 7天腹腔注射纳洛酮后分组对动物进行Morris水迷宫训练。结果 (1)在Morris水迷宫隐匿平台训练中 ,假手术组动物的逃避潜伏期最短 ,治疗组动物的逃避潜伏期比模型组明显缩短 (P <0 .0 5 ) ;(2 )探索实验中假手术组穿越次数最多 ,治疗组穿越次数又多于模型组 (P <0 .0 5 ) ;(3)可见平台学习中 ,三组动物的逃避潜伏期无明显组间差别 (P >0 .0 5 )。结论 纳洛酮可明显改善血管性痴呆大鼠的学习记忆能力
Objective To study the effect of naloxone on the learning and memory ability of vascular dementia rats. Methods The bilateral common carotid arteries were ligated. The vascular dementia model was prepared and divided into model group and treatment group randomly. Sham operation group was also established. The rats in the treatment group were administered with Morris water maze after intraperitoneal injection of naloxone for 7 consecutive days. Results (1) In the Morris water maze concealed platform training, the escape latency of the sham operation group was the shortest, the escape latency of the treatment group was significantly shorter than that of the model group (P <0.05); (2) (3) It can be seen that in the platform learning, the escape latency of the three groups of animals showed no significant difference between the groups (P> 0.05) . Conclusion Naloxone can significantly improve the learning and memory ability of vascular dementia rats