论文部分内容阅读
目的研究α-受体阻滞剂、COX-2抑制剂和抗抑郁药联合治疗慢性前列腺炎/慢性盆底疼痛综合征(CP/CPPS)的效果。方法本组57例被诊断为CP/CPPS的患者,平均年龄33岁(18～58岁)。均有骨盆区域疼痛不适、尿频、尿不尽感及紧张、焦虑等症状。平均病程10月(3月～2年)。均有抗生素治疗史,疗效不佳。采用α-受体阻滞剂(多沙唑嗪控释片4mg/d口服)、COX-2抑制剂(塞来昔布200mg/d口服)、抗抑郁药(舍曲林50mg/d口服)联合疗法,3月为一疗程。在治疗前、治疗后4周、8周和12周对患者进行美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)评分并记录不良反应情况。疗效评定标准为:(1)显效:NIH-CPSI较治疗前下降>15分;(2)有效:NIH-CPSI较治疗前下降>5分;(3)无效:NIH-CPSI较治疗前下降<5分或上升。总有效率为显效率与有效率之和。结果显效31例,有效18例,无效4例,总有效率92%(49/53)。2例患者因药物不良反应退出治疗。结论α-受体阻滞剂、COX-2抑制剂和抗抑郁药联合治疗方案安全有效,可以明显缓解CP/CPPS患者的临床症状。
Objective To investigate the effect of combination of α-blockers, COX-2 inhibitors and antidepressants on chronic prostatitis / chronic pelvic pain syndrome (CP / CPPS). Methods 57 patients were diagnosed as CP / CPPS patients, mean age 33 years (18 to 58 years). All have pelvic pain, urinary frequency, urinary symptoms and nervous, anxiety and other symptoms. The average duration of October (March ~ 2 years). Antibiotic treatment history, poor efficacy. The use of α-blockers (doxazosin controlled release tablets 4mg / d orally), COX-2 inhibitors (celecoxib 200mg / d orally), antidepressants (sertraline 50mg / d orally) Combination therapy, March for a course of treatment. Patients underwent NIH-CPSI scores before treatment, 4 weeks, 8 weeks, and 12 weeks after treatment and adverse events were recorded. (2) Effective: NIH-CPSI decreased more than 5 points before treatment; (3) Invalid: NIH-CPSI decreased compared with that before treatment < 5 points or up. The total effective rate for the efficiency and effectiveness of the sum. The results were markedly effective in 31 cases, effective in 18 cases, ineffective in 4 cases, the total effective rate was 92% (49/53). Two patients withdrew due to adverse drug reactions. Conclusion The combination of α-blockers, COX-2 inhibitors and antidepressants is safe and effective, which can significantly relieve the clinical symptoms of CP / CPPS patients.