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采用 EL ISA法检测 15 3例各类慢性肝病患者血清 IL-8水平。结果 ,血清 IL-8水平随 CH病变程度加重而呈递增趋势 ,但 AL C及 CSH组 IL-8水平较 CH中、重度组有所下降 ( P<0 .0 5 ) ;合并细菌感染者血清 IL-8水平明显高于未合并感染者( P<0 .0 1) ,感染者中 ,晚期肝病组与 CH组相比血清 IL-8水平无显著性差异 ( P>0 .0 5 ) ;按病原学分类 ,血清 IL-8水平依次为CHB+C>CHC>CHB,且 CHB+C和 CHC均与 CHB组有统计学差异 ( P<0 .0 5 )。因此 ,血清 IL-8检测有助于判断慢性病毒性肝炎肝损害严重程度 ,但其水平高低相对于合并细菌感染和肝损害严重程度而言与前者关系更为密切。此外 ,血清 IL-8明显升高可能与慢性 HCV感染较慢性 HBV感染更易发展为肝硬化 ,肝癌的特点有关
EL ISA method was used to detect serum IL-8 levels in 15 3 patients with various types of chronic liver diseases. As a result, the level of IL-8 in serum increased with the severity of CH. However, the levels of IL-8 in AL and CSH groups were lower than those in CH and CH groups (P <0.05). The serum levels of IL- The level of IL-8 in patients with advanced liver disease was significantly higher than those without infection (P <0.01). There was no significant difference in serum IL-8 levels between CHD patients and those with advanced liver disease (P> 0.05). According to the etiological classification, the level of serum IL-8 was CHB + C> CHC> CHB, and there was a significant difference between CHB + C and CHC with CHB group (P <0.05). Therefore, serum IL-8 test can help determine the severity of liver damage in chronic viral hepatitis, but its level is more closely related to the severity of combined bacterial infection and liver damage. In addition, a significant elevation of serum IL-8 may be associated with chronic HBV infection more likely to develop chronic hepatitis B cirrhosis and liver cancer