目的:探讨舌苔变化、血清表皮生长因子受体(EGFR)水平、临床检验指标与胃癌发生的相关性。方法:采用病例-对照法,ELISA测定86例胃癌患者和80例对照血清EGFR水平,非参数检验分析舌苔变化、血清EGFR水平、临床检验指标和胃癌发生的相关性。结果:胃癌组血清EGFR水平高于对照组,差异有显著性意义(P<0.05);特别是淋巴细胞百分比、中性粒细胞百分比、血红蛋白等临床检验指标正常的白苔或薄苔人群。血清EGFR水平与年龄无关,差异无显著性意义(P>0.05)。结论:对于临床检验指标正常的人群,观察舌苔类型与检测血清EGFR水平,对胃癌的早期防治可能有重要的意义。 Objective: To investigate the relationship between changes of tongue coating, serum epidermal growth factor receptor (EGFR), clinical test indexes and occurrence of gastric cancer. Methods: The EGFR levels in 86 gastric cancer patients and 80 controls were measured by case-control method. The changes of tongue coating, serum EGFR level, clinical test indexes and the incidence of gastric cancer were analyzed by non-parametric test. Results: The serum level of EGFR in gastric cancer group was significantly higher than that in control group (P <0.05), especially in the white moss or moss group with clinical test indexes such as lymphocyte percentage, neutrophil percentage and hemoglobin. Serum EGFR level has nothing to do with age, the difference was not significant (P> 0.05). Conclusion: It is of great significance to observe the type of tongue coating and detect the level of serum EGFR for the early detection and prevention of gastric cancer in people with normal clinical test.