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AIM: To study milk consumption and subjective milkrelated symptoms in adults genotyped for adult-type hypolactasia.METHODS: A total of 1900 Finnish adults were genotyped for the C/T-13910 variant of adult-type hypolactasia and filled in a structured questionnaire concing milk consumption and gastrointestinal problems.RESULTS: The C/C-13910 genotype of adult-type hypolactasia was present in 18% of the study population. The prevalence of the C/C-13910 genotype was higher among subjects who were undergoing investigations because of abdominal symptoms (24%,P ＜ 0.05). Those with the C/C-13910 genotype drank less milk than subjects with either the C/T-13910 or the T/T-13910genotype of lactase persistence (18% vs 38%; 18% vs36%, P ＜ 0.01). Subjects with the C/C-13910 genotype had experienced more gastrointestinal symptoms (84%)during the preceding three-month period than those with the C/T-13910 (79%, P ＜ 0.05) or the T/T-13910 genotype (78 %, P ＜ 0.05). Only 9% (29/338) of the subjects with the C/C-13910 genotype consumed milk and reported no symptoms from it.CONCLUSION: Gastrointestinal symptoms are more common among adults with the C/C-13910 genotype of adult-type hypolactasia than in those with genotypes of lactase persistence.