作者对β-内酰胺类抗生素与叔胺类药物如吩噻嗪类及三环抗抑郁剂在0.1M 枸橼酸盐缓冲液(pH4.8,μ=0.6,KCI)中的相互作用进行了研究。氯丙嗪、氯丙咪嗪(clomipramine)和苯唑青霉素(oxaci-llin)、邻氯青霉素(cloxacillin)出现显著的相互作用,先锋霉素 V(cefazolin)和先锋霉素I(Cep-haloThin)也形成混浊或生成少许沉淀,尤其是在先锋霉素 V 与左旋甲丙嗪(levomepromazine)的混 The authors performed an investigation of the interaction of β-lactam antibiotics with tertiary amine drugs such as phenothiazines and tricyclic antidepressants in 0.1 M citrate buffer (pH 4.8, μ = 0.6, KCI) the study. Chlorpromazine, clomipramine and oxaci-llin, and cloxacillin showed significant interaction with cefazolin and Cep-haloThin, Also forms turbid or forms a small precipitate, especially in the mixture of cephalosporin V and levomepromazine