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目的建立快速、有效合成正电子发射体层摄影(PET)示踪剂11C-乙酸的方法并研究其生物分布,满足临床PET的用药需要。方法以11C-CO2为原料,与CH3MgBr反应后再用17%的H3PO4酸解,产物通过加热的方法蒸出,同时通过控制11C-CO2的释放速度和适当延长11C-CO2与CH3MgBr的反应时间,提高反应产率。小鼠给药后不同时间处死,分别取不同器官称重并测放射线计数。结果从加速器生产出11C-CO2到产物11C-乙酸的蒸出完毕,需15min,放化纯度大于98%,化学纯度大于99%,平均产率为34.6%(未经衰变校正)。注射11C-乙酸后,放射线主要集中在肝脏及肾脏。结论改进反应条件后的合成方法具有快速、高效的特点,为PET日常耗材节省了成本,提高了用药的质量。
Objective To establish a rapid and effective method for synthesizing positron emission tomography (PET) tracer 11C-acetic acid and to study its biodistribution to meet the need of clinical PET. Methods 11C-CO2 was reacted with CH3MgBr and then acidified with 17% H3PO4. The product was evaporated by heating. By controlling the release rate of 11C-CO2 and the reaction time of 11C-CO2 with CH3MgBr, Improve the reaction yield. Mice were sacrificed at different times after administration, and different organs were weighed and radiation counts were measured. Results The 11C-CO 2 produced from the accelerator and the 11C-acetic acid product were distilled off in 15 min. The radiochemical purity was over 98%. The chemical purity was over 99% and the average yield was 34.6% (without decay correction). After injection of 11C-acetic acid, the radiation mainly concentrated in the liver and kidney. Conclusion The synthetic method after improving the reaction conditions has the characteristics of fast and high efficiency, saves the cost for PET daily consumables and improves the quality of medication.