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目的对未足月胎膜早破(preterm premature rupture of membranes,PPROM)患者阴道微生态环境进行全面评价,探讨其临床意义。方法选取22~37周的PPROM孕妇100例,同时选取同期正常孕妇70例为对照组,采集阴道分泌物,对阴道菌群进行全面评价。结果 PPROM孕妇阴道分泌物过氧化氢(H2O2)的阳性率低于对照组;细菌性阴道病(bacterial vaginosis,BV)、外阴阴道假丝酵母菌病(vulvovaginal candidiasis,VVC)的患病率,无症状及体征的微生态失调状态发生率均高于对照组(P<0.05)。结论 PPROM孕妇与正常孕妇阴道菌群微生态不同,推测菌群失调可能为未足月胎膜早破发生的机制。
Objective To evaluate the vaginal microenvironment of patients with preterm premature rupture of membranes (PPROM) and discuss its clinical significance. Methods 100 cases of PPROM from 22 to 37 weeks were selected. At the same time, 70 pregnant women of the same period were selected as the control group. Vaginal secretions were collected and the vaginal flora was evaluated comprehensively. Results The positive rate of hydrogen peroxide (H2O2) in vaginal secretions of PPROM pregnant women was lower than that in control group. The prevalence of bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) The incidence of symptoms and signs of microecological disorders were higher than the control group (P <0.05). Conclusion PPROM pregnant women and normal pregnant women vaginal flora different microbial speculation that flora may be the mechanism of premature rupture of membranes.