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目的:对改良董氏开胃贴治疗湿食困脾型厌食症患儿的临床疗效做出评价,并观察其对胃肠激素的影响。方法:受试患儿随机分入试验组和对照组,观察患儿的症状、体征以及临床实验室指标,将治疗后患儿证候积分以及观察指标与治疗前进行对照,所有病例收集完毕后进行统一破盲,统计分析,得出结论。结果:试验组与对照组治疗后的证候积分较治疗前均有所改善,P<0.05,有显著性差异。试验组治疗后总有效率95.5%;对照组治疗后总有效率95.7%。两组组间疗效比较,P>0.05,差异无统计学意义。两组治疗后唾液淀粉酶、胃泌素、β-EP与治疗前比较,均有改善,P<0.05,差异有统计学意义,但CCK-8治疗后无明显改善,P>0.05,差异无统计学意义。研究过程中两组均未发生不良反应。结论:改良董氏开胃贴治疗湿食困脾型厌食症有确切疗效,具有消积导滞、健脾开胃的功效,对胃肠激素的分泌起到积极的作用。
OBJECTIVE: To evaluate the clinical efficacy of modified Dong’s appetizer for the treatment of children with wet-spleen-type anorexia and to observe their effects on gastrointestinal hormones. Methods: The children were randomly divided into test group and control group. The symptoms, signs and clinical laboratory parameters of children were observed. After treatment, the scores of children’s syndromes and the observed indexes were compared with those before treatment. After all the cases were collected Unite to break the blind, statistical analysis, draw conclusions. Results: The scores of syndromes in experimental group and control group after treatment were all improved, P <0.05, there was significant difference. The experimental group after treatment, the total effective rate was 95.5%; control group after treatment, the total effective rate was 95.7%. The curative effect between the two groups, P> 0.05, the difference was not statistically significant. The saliva amylase, gastrin and β-EP in both groups improved after treatment, P <0.05, the difference was statistically significant, but no significant improvement after CCK-8 treatment, P> 0.05, no difference Statistical significance. No side effects occurred in both groups during the study. Conclusion: The modified Dong’s appetizer stickers for the treatment of wet food spleen anorexia have the exact effect, with the consumer product stagnation, spleen appetizers effect on the secretion of gastrointestinal hormones play a positive role.