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目的 :观察硝酸镧对 Hep- 2喉癌细胞体外增殖生长的影响。方法 :在体外硝酸镧浓度为 0 .0 5 m mol/ L～ 3.2 mm ol/L 的培养条件下 ,采用 MTT实验检测喉癌细胞生长抑制率以及测定喉癌细胞的克隆形成率。结果 :在 0 .4 m mol/ L～3.2 mm ol/ L 范围内 ,硝酸镧增加喉癌细胞生长抑制率与降低其克隆形成率。结论 :硝酸镧在体外培养中对喉癌细胞增殖有一定的抑制作用并可能促其向良性分化。
Objective: To observe the effect of lanthanum nitrate on the proliferation of Hep-2 cell in vitro. METHODS: The growth inhibition rate of laryngeal cancer cells and the colony formation rate of laryngeal cancer cells were measured by MTT assay under the conditions of 0.5-5.0 m mol/L-3.2 mm ol/L in vitro. Results: In the range of 0. 4 m mol/L to 3.2 mm ol/L, lanthanum nitrate increased the growth inhibition rate of laryngeal carcinoma cells and decreased the colony formation rate. Conclusion: Lanthanum nitrate can inhibit the proliferation of laryngeal cancer cells in vitro and may promote benign differentiation.