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作者在研究羟氨啉的作用方式中,测定了曼氏血吸虫病小鼠口服或肌注~(14)C-羟氨喹后的血药浓度与血吸虫雌、雄虫对该药的摄入量及贮存量。小鼠感染曼氏血吸虫尾蚴80条,8～10周后分组给予口服或肌注~(14)C-羟氨喹(放射活性为5.6微居里/毫克)单剂50毫克/公斤体重(ED_(99)剂量)。给药后隔不同时间解剖,从腔静脉取血,分离血清,取200微升血清在液体闪烁计数器中测定放射性。并收集肠系膜静脉及肝窦中的成虫,以生理盐水洗涤,置于含有戊巴比妥1微克/毫升的盐水中,使
The author in the study of the role of hydroxamines mode, the determination of Schistosoma mansoni in mice oral or intramuscular injection of ~ (14) C-amidocampol after the blood concentration and schistosome female and male intake of the drug And storage capacity. Mice were challenged with 80 schistosoma mansoni cercariae and given a single dose of 50 mg / kg body weight (ED_ (14) C-hydroxyquinoline (5.6 μCi / mg) orally or intramuscularly 8-10 weeks later) (99) dose). At different time intervals after administration, blood was drawn from the vena cava and the serum was separated. Two hundred microliters of serum was measured for radioactivity in a liquid scintillation counter. Mesenteric veins and adult sinusoids were collected, washed with saline and placed in saline containing 1 μg / ml pentobarbital