自发痛是临床神经源性痛患者重要的疼痛主诉,但临床上自发痛很难测量,最近有研究利用条件位置偏爱范式负强化原理研究了神经源性痛引起的自发痛的特征及其机制。King等研究者利用了条件位置偏爱范式探索传入神经和上行感觉束在脊神经结扎(SNL)模型引起的自发痛中的作用,揭示了它们在SNL引起 Spontaneous pain is a major complaint of pain in patients with clinical neurogenic pain. However, it is difficult to measure spontaneous pain in clinical practice. Recently, studies have investigated the characteristics and mechanism of spontaneous pain caused by neurogenic pain using the negative reinforcement principle of conditional place preference paradigm. Researchers at King et al used the conditional-preference paradigm to explore the role of afferent and upstream sensory bundles in spontaneous pain induced by the spinal nerve ligation (SNL) model, revealing that they are caused by SNL