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目的:为评估由三苯氧胺、环磷酰胺、氨甲喋呤和顺铂组成的TCMP方案对常规化疗耐药后复发转移性乳腺癌的疗效.方法:25例对常规化疗耐药的复发转移性乳腺癌患者接受TCMP方案化疗.给药方法是三苯氧胺,10mg,口服,每天2次;环磷酸胺,0.8～1.0,静推,第1天;氨甲喋呤,40mg,肌注,第1、8天;顺铂40mm,静滴,第1～4天.23例患者有客观评价指标,均接受TCMP方案化疗最小2周期.结果:23例可评价患者中,总客观有效率为52.17%(95%可信区间31～73%),其中2例CR,10例PR.经Ridit检验治疗效果与雌激素受体状态无关.结论:以上提示TCMP方案对常规治疗耐药后复发转移性乳腺癌有较好疗效,三苯氧胺与以顺铂为主化疗方案在乳腺癌的治疗中有协同作用.
OBJECTIVE: To evaluate the efficacy of TCMP regimen consisting of tamoxifen, cyclophosphamide, methotrexate and cisplatin on relapsed metastatic breast cancer after conventional chemotherapy resistance. METHODS: Twenty-five patients with relapsed metastatic breast cancer who were resistant to conventional chemotherapy were accepted. TCMP regimen chemotherapy. Dosing method is tamoxifen, 10mg, orally, twice daily; Cyclophosphamide, 0.8-1.0, static push, day 1; methotrexate, 40mg, intramuscular, first, 8 days, cisplatin 40mm, Intravenously, on the 1st to 4th days, 23 patients had objective evaluation indicators and received TCMP chemotherapy for a minimum of 2 cycles. Results: In 23 evaluable patients, the total objective effective rate was 52.17% (95% confidence interval 31- (73%), of which 2 cases had CR and 10 had PR. The treatment effect by Ridit test was not related to the status of estrogen receptor. Conclusion: The above indicates that the TCMP regimen has better efficacy in the treatment of relapsed metastatic breast cancer after conventional therapy. Tamoxifen The cisplatin-based chemotherapy regimen has a synergistic effect in the treatment of breast cancer.