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目的:探讨血管内皮细胞黏附分子(VCAM-1)在呼吸道变应性炎症患者中的表达和意义。方法:将39名患有变应性鼻炎并哮喘的患者和21例仅患有变应性鼻炎的患者分成两组,取鼻腔黏膜和支气管黏膜进行活组织病理检查,并用免疫组织化学的方法对VCAM-1的表达进行检测。结果:变应性鼻炎并哮喘组支气管黏膜中嗜酸粒细胞数显著高于变应性鼻炎组(t=12.81,P<0.01),变应性鼻炎组鼻腔黏膜中VCAM-1阳性细胞比例与变应性鼻炎并哮喘组相比差异无统计学意义。变应性鼻炎并哮喘组支气管黏膜中VCAM-1阳性细胞比例显著高于变应性鼻炎组(t=9.43,P<0.01),变应性鼻炎并哮喘组支气管黏膜中VCAM-1阳性细胞比例和支气管黏膜嗜酸粒细胞数呈显著正相关(r=0.783,P<0.01)。结论:VCAM-1表达的上调,导致呼吸道变应性炎症的蔓延。
Objective: To investigate the expression and significance of vascular endothelial cell adhesion molecule (VCAM-1) in patients with respiratory allergic inflammation. Methods: Thirty-nine patients with allergic rhinitis and asthma and 21 patients with allergic rhinitis were divided into two groups. The nasal mucosa and bronchial mucosa were taken for biopsy and immunohistochemistry VCAM-1 expression was detected. Results: The number of eosinophils in bronchial mucosa of allergic rhinitis and asthma group was significantly higher than that of allergic rhinitis group (t = 12.81, P <0.01). The percentage of VCAM-1 positive cells in nasal mucosa of allergic rhinitis group was Allergic rhinitis and asthma group compared with no significant difference. The proportion of VCAM-1 positive cells in bronchial mucosa of allergic rhinitis and asthma group was significantly higher than that in allergic rhinitis group (t = 9.43, P <0.01). The proportion of VCAM-1 positive cells in bronchial mucosa of allergic rhinitis and asthma group And bronchial mucosal eosinophil number was significantly correlated (r = 0.783, P <0.01). Conclusion: Upregulation of VCAM-1 expression leads to the spread of respiratory allergic inflammation.