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目的 :观察氧氟沙星聚乳酸缓释植入药栓眼内组织相溶性及生物降解过程。方法 :1 将自制的氧氟沙星聚乳酸缓释药栓经平坦部巩膜切口植入 11只兔眼玻璃体腔 ,在每只兔植入前 1～ 3天和植入后 3～2 6天作ERG检测 ,取其b波振幅进行配对t检验统计分析。 2 在植入药栓后 7天和 2 1天 ,作临近的内层眼球壁组织电镜和光镜检查。 3 在植入药栓后 2～ 14周作组织切片观察药栓降解过程和眼组织反应。结果 :1 药栓植入前后b波振幅配对t检验差异无显著意义 (P >0 0 5 ) ;2 在药栓植入后 7天和 2 1天电镜和光镜检查视网膜组织无病理性改变 ;3 在药栓植入早期眼组织有轻微异物性炎症反应 ,药栓逐渐降解吸收。结论 :氧氟沙星聚乳酸缓释药栓在眼内玻璃体腔具有良好的组织相溶性 ,并能逐渐降解吸收
OBJECTIVE: To observe the intra-ocular tissue compatibility and biodegradation of ofloxacin polylactic acid sustained release implanted suppository. Methods: The self-made ofloxacin polylactic acid sustained-release drug suppository was implanted into the vitreous cavity of 11 eyes of rabbits through the scleral incision of the flat part. The rabbits were implanted 1 to 3 days before and 3 to 26 days For ERG detection, whichever b wave amplitude paired t-test statistical analysis. 2 At 7 days and 21 days after implantation of the suppository, electron microscopy and light microscopy were performed on the adjacent inner eyeball wall. 3 2 to 14 weeks after implantation of the suppository for histological sections to observe the degradation process and ocular tissue reaction. Results: 1 There was no significant difference in paired t-test between b-wave amplitudes before and after bolus implants (P> 0.05) .2 There was no pathological changes of retinal tissue under electron microscope and light microscope 7 days and 21 days after implanted. 3 in the early implantation of suppository eye tissue slight foreign body inflammation, drug suppository gradually absorb. Conclusion: ofloxacin polylactic acid sustained-release suppository has good histocompatibility in the vitreous cavity of the eye and can gradually degrade and absorb