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目的探讨甲泼尼龙在中重度支气管哮喘急性发作中的应用效果。方法选择我院2009年7月-2011年7月支气管哮喘患者共80例,分为观察组和对照组,均给予吸氧、补液等治疗,给予多索茶碱0.2g口服,2次/d,给予硫酸沙丁胺醇0.5ml加入3ml生理盐水中雾化吸入。在以上基础上,对照组患者给予布地奈德2mg,雾化吸入,2次/d。观察组患者给予甲泼尼龙80mg静脉滴注,2次/d。观察两组患者治疗前和治疗5d后临床症状的改善情况,测定治疗前和治疗5d后动脉血气指标改善情况。结果观察组治疗后动脉血氧分压与对照组治疗后比较,差异有统计学意义(P<0.05);观察组临床症状改善有效率高于对照组,差异有统计学意义(P<0.05)。结论甲泼尼龙能够显著改善中重度支气管哮喘急性发作临床症状,改善血气状况,临床效果显著。
Objective To investigate the application of methylprednisolone in acute exacerbation of moderate-severe bronchial asthma. Methods A total of 80 patients with bronchial asthma were selected from July 2009 to July 2011 in our hospital. The patients were divided into observation group and control group. All patients were given oxygen and rehydration therapy. The patients were treated with doxofylline 0.2g twice daily , Given salbutamol 0.5ml 3ml saline inhalation. Based on the above, the control group patients given budesonide 2mg, inhalation, 2 times / d. Patients in the observation group were given methylprednisolone 80mg intravenously, twice a day. The improvement of clinical symptoms in both groups before treatment and after 5 days of treatment was observed. The improvement of arterial blood gas index before treatment and after 5 days of treatment were observed. Results After the treatment, the partial pressure of arterial oxygen in the observation group was significantly lower than that in the control group (P <0.05), and the effective rate of clinical symptom improvement in the observation group was higher than that in the control group (P <0.05) . Conclusion Methylprednisolone can significantly improve the clinical symptoms of acute exacerbation of moderate-severe bronchial asthma and improve blood gas condition, with a significant clinical effect.