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目的 探讨脑血管病患者肿瘤坏死因子α(TNF α)与C反应蛋白 (CRP)的动态变化及其在脑组织损伤中的免疫调控机制。方法 用放免法检测 12 0例患者和 76例正常人TNF α的含量 ;用免疫比浊法测定CRP的含量。结果 急性期脑血管病患者血TNF α和CRP含量均明显增高 ,与正常组比较有显著性差异 (P <0 .0 1)。结论 脑血管病患者早期有炎性反应 ,TNF α和CRP均参与脑组织损伤的免疫调控。
Objective To investigate the dynamic changes of tumor necrosis factor α (TNF α) and C-reactive protein (CRP) in patients with cerebrovascular disease and its mechanism of immune regulation during brain injury. Methods The levels of TNFα in 120 patients and 76 normal subjects were detected by radioimmunoassay. The levels of CRP were determined by immunoturbidimetry. Results The levels of TNFα and CRP in patients with acute cerebrovascular disease were significantly higher than those in the normal group (P <0.01). Conclusions The patients with cerebrovascular disease have early inflammatory reaction, and both TNFα and CRP are involved in the immune regulation of brain injury.