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声带白斑是由刺激因素长期作用于声带黏膜，导致声带黏膜上皮生长异常或成熟异常及过度角化而引起的一种白色斑块样疾病。“白斑”一词，仅为一临床描述性名词，用于描述黏膜上不易擦去的、非特殊病变（例如念珠菌感染）引起的白色病灶。声带白斑多伴有不同程度的不典型增生，有一定的癌变率，但既往将其完全等同于癌前病变有失偏颇，目前已达成共识，认为声带白斑只作为一个临床诊断，本身并无组织病理学暗示。对声带白斑与癌前病变的关系以及声带白斑的形成机制、组织病理学分类、临床诊断及治疗方面进行综述。“,”Vocal cord leukoplakia is a white-plaque disease due to long-term stimulation on vocal cords,which includes abnormal epithelial hypertrophy and dysplasia of the vocal cord.The term “white plaque”is clinically describing any white lesion on a mucous membrane that cannot be wiped off or ascribed to any specific condition (eg,Candidal infec-tion).There is a consensus that vocal cord leukoplakia has no histologic implications and synonymous with cancer or malignancy,only as a clinical descriptive diagnosis.In this paper,we reviewed the relationship between vocal cord leu-koplakia and premalignant lesions and the formation mechanism,histopathologic classification,clinical diagnosis and treatment of vocal cord leukoplakia.