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目的 :观察达纳康对 ICAM- 1的抑制及对 NO的保护。方法 :选用非开颅线栓法造成大脑中动脉缺血 ,缺血 2 h后将插入的线向外拉出 1cm,形成再灌注。分别在再灌注 12 h,2 4h,48h时间点将大鼠处死。迅速从心脏取血 (约1~ 2分钟 )。结果 :在不同再灌注时间下 ,单纯再灌注各组间 ICAM- 1有显著变化 ,在相同再灌注时间下 ,单纯再灌注组 ICAM- 1明显高于达纳康组 ,NO显著低于达康组。结论 :在再灌注早期 ICAM- 1有显著的上升 ,而达纳康药物对ICAM- 1有明显的抑制作用 ,有利于 NO释放的增加 ,促使血管的扩张 ,增加了缺血区的供血。即达纳康对血管内皮有保护作用 ,增加血管张力 ,减轻了再灌注的又一次损伤。
OBJECTIVE: To observe the inhibitory effect of Danakang on ICAM-1 and the protection of NO. Methods: The non-craniotomy occlusion method was used to induce cerebral ischemia in the middle cerebral artery. After 2 h of ischemia, the inserted line was pulled out 1 cm outward to form a reperfusion. Rats were sacrificed 12 h, 24 h and 48 h after reperfusion, respectively. Quickly take blood from the heart (about 1 to 2 minutes). Results: Under different reperfusion time, the ICAM-1 in the reperfusion group changed significantly. Under the same reperfusion time, ICAM-1 in the reperfusion group was significantly higher than that in the danacan group group. CONCLUSION: ICAM-1 is significantly increased in the early stage of reperfusion, while danacone obviously inhibits ICAM-1, promotes the increase of NO release, promotes the expansion of blood vessels and increases the blood supply of ischemic area. That Danan Kang on vascular endothelial protection, increase vascular tone, reduce reperfusion injury again.