本刊讯国家食品药品监管总局日前发布了第63期《药品不良反应信息通报》,提示关注丙硫氧嘧啶的严重不良反应。丙硫氧嘧啶是一种硫代酰胺药物,能抑制甲状腺过氧化物酶,从而阻断甲状腺激素生成,主要用于治疗成人甲状腺功能亢进症,其严重的不良反应主要包括肝功能异常、肝细胞损害、肝炎、胆红素升高、白细胞减少症、粒细胞缺乏症等。近期,国内药品不良反应监测数据及相关文献资料表明,在长期使用丙硫氧嘧啶的患者中,可能出现抗中性粒细胞胞浆抗体(ANCA)相关性血管炎,可累及全身多个器官和(或)系统,如肾脏、肺脏和关节等。累 Benxi Xin State Food and Drug Administration recently released the first 63 “Adverse Drug Reaction Information”, prompted attention to propylthiouracil serious adverse reactions. Propylthiouracil is a thioamide drugs, can inhibit the thyroid peroxidase, which block the thyroid hormone production, mainly for the treatment of hyperthyroidism in adults, and its serious adverse reactions include liver dysfunction, liver cells Damage, hepatitis, elevated bilirubin, leucopenia, agranulocytosis and so on. Recently, the domestic adverse drug reaction monitoring data and related literature show that anti-neutrophil cytoplasmic antibody (ANCA) -related vasculitis may occur in long-term use of propylthiouracil in patients with multiple organs and (Or) system, such as the kidneys, lungs and joints. tired