通过合成促生长激素释放肽,对四氢噻唑-2-硫酮(TTT)活泼酰胺法在固相肽合成中的应用进行了研究。实验结果表明,TTT活泼酰胺同载体上的氨基组分的缩合反应速度很大,每步缩合反应的产率很高(>99.3％),最终产品的纯度也很令人满意。此外,还报道了合成肽的生物活性。 The application of tetrahydrothiazole-2-thione (TTT) activated amide method in the synthesis of solid-phase peptide was studied by the synthesis of somatostatin. The experimental results show that the condensation reaction of TTT active amide with the amino component on the carrier is very rapid, the yield of each condensation reaction is very high (> 99.3%), and the purity of the final product is also very satisfactory. In addition, the biological activity of synthetic peptides has also been reported.