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患者随机分为黄连素治疗组 (1 8例 )和对照组 (1 7例 )。两组糖尿病患者治疗前后测定红细胞AR ,血糖、血常规、血生化、肝功能、肾功能 ,同时测定尿白蛋白排泄率 (UAER) ,血、尿 β2 -微球蛋白 (β2 -MG)。治疗过程中观察、记录两组病人出现的副作用 ,疗程 4周。结果 :上述指标治疗前二组相似 ,治疗后治疗组AR活性受到抑制 ,明显低于对照组 ,UAER ,血 β2 -MG明显低于对照。治疗过程中未发现明显副作用。结论 :黄连素可明显抑制AR活性 ,改善DN的各项指标 ,有助于DN的治疗
Patients were randomly divided into berberine treatment group (18 cases) and control group (17 cases). The levels of AR, blood glucose, blood routine, blood biochemistry, liver function and renal function were measured before and after treatment in two groups of diabetic patients. Urinary albumin excretion rate (UAER), blood and urine β2 - microglobulin (β2 - MG) were measured at the same time. Observation and treatment during treatment recorded the side effects of two groups of patients, the course of treatment for 4 weeks. Results: The above indexes were similar in the two groups before treatment. After treatment, the AR activity was inhibited in the treatment group, which was significantly lower than that in the control group. The UAER and blood β2-MG were significantly lower than those in the control group. No obvious side effects were found during treatment. Conclusion: Berberine can significantly inhibit the activity of AR and improve various indexes of DN, which is helpful for the treatment of DN