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目的探讨乳酸脱氢酶对妊娠期可逆性后部白质脑病综合征(RPLS)的变化及意义。方法回顾性分析住院患者126例,按妊娠期RPLS分为四组。正常产妇40例,轻度脑水肿44例,中度脑水肿34例,重度脑水肿8例。对四组的一般情况、乳酸脱氢酶及新生儿的情况进行对比分析。结果四组之间乳酸脱氢酶之间比较,差异有统计学意义(P<0.01);重度脑水肿孕妇LDH水平明显高于中度、轻度脑水肿孕妇,进一步两两比较,各组间孕妇LDH水平比较,差异均有统计学意义(P<0.05)。四组之间进行新生儿体重比较差异明显,有统计学意义(P<0.01)。不同LDH水平新生儿出生体重差异有统计学意义(P<0.05),孕产妇LDH的升高,新生儿的体重明显减低。结论乳酸脱氢酶能监测妊娠期可逆性后部白质脑病综合征的的病情进展,预测母婴预后。
Objective To investigate the changes and significance of lactate dehydrogenase in reversible posterior leukoencephalopathy syndrome (RPLS) during pregnancy. Methods A retrospective analysis of 126 inpatients was divided into four groups according to RPLS during pregnancy. 40 cases of normal maternal, mild brain edema in 44 cases, 34 cases of moderate cerebral edema, severe cerebral edema in 8 cases. The general situation of the four groups, lactate dehydrogenase and neonatal comparative analysis. Results There was a significant difference between lactate dehydrogenase among the four groups (P <0.01). LDH levels in pregnant women with severe cerebral edema were significantly higher than those in moderate and mild brain edema. For further comparison, LDH levels in pregnant women, the differences were statistically significant (P <0.05). There was significant difference in neonatal weight between the four groups (P <0.01). The birth weight of neonates with different levels of LDH was significantly different (P <0.05). The LDH of pregnant women was increased and the weight of neonates was significantly decreased. Conclusions Lactate dehydrogenase can monitor the progress of reversible posterior encephalopathy syndrome in pregnancy and predict the prognosis of maternal and infant.