,Alternative splice site recognition based on a new fuzzy support vector machine

来源 :生物化学与生物物理学报(英文版) | 被引量 : 0次 | 上传用户:weiqiwin
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Accurate alteative splice site (ASS) recognition is an important and difficult topic in the gene identification,and the average recognition rate is still < 85% [1].Many statistical patte recognition methods,such as neural networks (NNs)and support vector machine (SVM),were used for this task [2,3].Among them,SVM can construct a good highdimensional leaing model in the case of limited training set size and has good generalization ability,which exhibits many unique advantages in solving the small sample,non-linear,and high-dimensional patte recognition problems [4].To reduce the impact of noise samples on constructing optimal hyperplane,fuzzy SVM (FSVM) method was proposed [5].Each sample was assigned a different membership and had different contributions to the objective function.Because the noise samples had smaller memberships,and their effects on the separating hyperplane were reduced or eliminated.
其他文献
Obesity is an important inducing factor for type 2 diabetes.However,the mechanism underlying high-fat-(HF) dietinduced obesity in pancreatic beta cell dysfuncti
期刊
为探讨动态心电图ST-T改变在冠心病诊断中的临床意义,笔者对2006-03-2009-06就诊于我院24 h动态心电图有ST-T改变且行冠状动脉造影的126例患者进行了回顾性分析,现报告如下。
Biological therapy is one of the essential cancer treatments [1].The key issues of gene therapy are:whether the right carrier could be chosen,determining if the
期刊
苜蓿属有些种,通过种间杂交形成的大量的各种变异苜蓿(Medicago variaMart)类型,在自然条件下已经得到了广泛的普及。由 B.M.拉比诺维奇等在国家南部地区进行的研究表明:利
目的 了解切开复位内固定对治疗跟骨骨折的临床效果,研究跟骨骨折切开复位内固定对踝关节稳定性的影响.方法 对60例跟骨骨折患者进行切开复位内固定治疗,比较术前及术后的临
Autophagy is an evolutionarily conserved cellular degradation process,in which intracellular components are digested by the lysosomal pathway.While this process
期刊
丙氨酸氨基转移酶(ALT)作为肝功能检测的指标之一,在肝炎的临床诊断及防治方面具有重要的临床意义.在无偿献血者血液检测中,ALT是对无偿献血者进行血液筛查的一项非特异性指
中共中央政治局常委、国务院副总理李克强近日在河北省廊坊市召开保障房建设现场座谈会并讲话。他指出,要继续扎实推进保障性安居工程建设,把好质量安全关、公平分配关,更好
目的 对重症监护病房(ICU)连续发生鲍曼不动杆菌医院感染进行调查,为控制医院感染提供依据和对策.方法 按要求采样.按细菌分离培养进行菌株鉴定和药敏试验.结果 患者痰标本和
急性冠脉综合征(ACS)根据其初始心电图改变分为ST段抬高性心肌梗死和非ST段抬高性ACS两大类。非ST段抬高性ACS包括非ST段抬高性心梗和不稳定型心绞痛,病情不稳定,需要恰当的