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目的 :探讨一氧化氮 (NO)及内皮素 (ET)在恙虫病患者的含量水平及其意义。方法 :采用镉还原比色法和放射免疫分析测定了 36例恙虫病患者的血浆NO和ET水平 ,并与 2 0名正常者进行对照。结果 :36例恙虫病患者急性期血浆NO和ET含量水平明显高于正常对照组 (P <0 .0 1) .恢复期NO和ET水平回复正常(P >0 .0 5 )。且NO与ET水平呈直线正相关 (P <0 .0 1)。结论 :一氧化氮和内皮素在恙虫病的发病机制中可能有重要作用。
Objective: To investigate the content and significance of nitric oxide (NO) and endothelin (ET) in patients with scrub typhus. Methods: Plasma NO and ET levels were measured in 36 patients with scrub typhus using cadmium reduction colorimetry and radioimmunoassay, and were compared with 20 normal controls. Results: The levels of plasma NO and ET in 36 patients with scrub typhus were significantly higher than those in normal controls (P <0.01), and the levels of NO and ET returned to normal after recovery (P> 0.05). There was a linear positive correlation between NO and ET (P <0.01). Conclusion: Nitric oxide and endothelin may play an important role in the pathogenesis of scrub typhus.