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环孢菌素A(cyclosporine A,CsA)是强效免疫抑制剂,广泛应用于器官移植,防止器官移植后的排异反应,使肾移植成功率和患者生存率大大提高.肾移植患者需长期服用CsA.CsA药物血药浓度监测与其他药物相比非常特殊,不同的测定方法与样本,测得值有一定的差异;患者对CsA药效的敏感性与耐受性有很大的个体差异;临床上中毒与排异反应不易区别;CsA血药浓度受到生理、病理、食物及合并用药诸多因素影响.如何对
Cyclosporine A (CsA) is a potent immunosuppressive agent widely used in organ transplantation to prevent rejection after organ transplantation and greatly improve the success rate of kidney transplantation and patient survival. Compared with other drugs, the monitoring of blood concentration of CsA-CsA drugs was very special. There were some differences between the measurement methods and the samples and the measured values. There was a great individual difference in the sensitivity and tolerability of CsA ; Clinical poisoning and rejection is not easy to distinguish; CsA plasma concentration by physiological, pathological, food and the combination of medication and many other factors.