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目的观察一株解脂假丝酵母菌种培养物的经口动物毒性。方法将解脂假丝酵母菌种分别接种于马铃薯-酵母膏-蔗糖、麦芽汁-蛋白胨及麦芽汁-酵母膏3种不同的产毒培养基,培养14d后,使用其培养物原液及2.5倍浓缩液,经口一次性灌胃给予ICR小鼠,雌雄各半,并随后连续观察14d中小鼠的中毒表现及死亡情况。结果其培养物对实验动物未见有毒性反应或死亡。结论初步证明了解脂假丝酵母的安全性。
Objective To observe the oral toxicity of a strain of Candida lipolytica. Methods The Candida lipolytica strains were inoculated into three kinds of toxin-producing mediums of potato-yeast extract-sucrose, wort-peptone and wort-yeast extract, respectively. After 14 days of culture, Concentrate, orally administered once a gavage ICR mice, male and female, and then continuously observed 14d in mice poisoning performance and death. As a result, no toxicity or death of the culture was observed in the test animals. Conclusion The safety of Candida lipolytica was initially proved.