In this paper, the inhomogeneous structure of generalized seismic strain release time series (GSSRTS) of earthquakes in East, West China and their subtectonic regions as Xinjiang, Qinghai-Xizang (Tibetan) Plateau,Northeast China, North China, South China and Taiwan have been analyzed by using the method of significant analysis on zero crossings of derivatives (SiZer). Results show that when index ηfor estimating GSSRTS is close to zero and bandwidth is large enough, GSSRTSs feature significant increasing in Xinjiang, Northeast China,South China and Taiwan tectonic regions and decreasing in Qinghai-Xizang (Tibetan Platean) and North China tectonic regions from January 1, 1970 to January 1, 2000. While with the dwindling of bandwidth GSSRTSs in all the above tectonic regions characterize clustering, that is to say, significant increasing and decreasing emerge alternatively. When ηis large enough, GSSRTSs would have no significant statistical variation in most of above tectonic regions except Qinghai-Xizang (Tibetan Platean) and Taiwan where significant increasing or decreasing hold in several time intervals within limited bandwidths.