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麻醉动物、清醒动物以及自发性高血压大鼠,iv苦马豆总黄酮甙后,均有显著的降压作用,起效快,持续时间短。降压机理与交感神经节阻断作用和直接扩张血管作用有关。血流动力学实验表明,苦马豆总黄酮甙对心肌收缩力和心率均无明显影响。由于外周扩血管作用而使总外周阻力明显降低。
Anesthetic animals, conscious animals and spontaneously hypertensive rats iv iv total glycosides glycosides, have a significant antihypertensive effect, rapid onset, short duration. Antihypertensive mechanism and sympathetic ganglia blockade and direct dilatation of blood vessels. Hemodynamics experiments show that the total flavonoid glycosides of horseradish have no significant effect on myocardial contractility and heart rate. Due to the role of peripheral vasodilation so that the total peripheral resistance was significantly reduced.