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目的:确定防治手足口病卫气同病证的中药处方最佳配伍。方法:实验通过对新疆地产药材通过临床初步筛选后确立初步处方,以临床治愈标准作为评价指标,采用正交设计优化其组方,并将优化所得处方于初步处方进行临床疗效比较。结果:应用正交设计法筛选出中药治疗手足口病方中中药的最佳配伍为新贝母3g,鱼腥草4g,白鲜皮5g,金银花4g,连翘4g,黄芩5g,前胡5g,荆芥3g,紫草5g,牡丹皮5g,大青叶4g,蒲公英8g,青蒿5g,此最佳配伍组合临床疗效较初步处方有显著的差异性。结论:应用正交设计与药效学验证试验相结合确定复方药物配伍的方法是可行的,所得处方各味药物配伍关系存在合理性。
Objective: To determine the best compatibility of traditional Chinese medicine prescriptions for the prevention and treatment of hand, foot and mouth disease with the same syndrome. Methods: Through the preliminary screening of Xinjiang real estate herbs through clinical preliminary screening, the clinical cure standard was used as the evaluation index, the orthogonal design was used to optimize its prescription, and the optimized prescription was compared in the preliminary prescription. Results: The orthogonal design was used to screen out the best compatibility of traditional Chinese medicine for the treatment of hand, foot and mouth disease. The best compatibility of traditional Chinese medicine was 3g of new Fritillaria, 4g of Houttuynia cordata, 5g of fresh white skin, 4g of honeysuckle, 4g of forsythia, 5g of scutellaria baicalensis, , Nepeta 3g, Lithospermum 5g, Cortex Moutan 5g, Folium 4g, dandelion 8g, Artemisia annua 5g, the best combination of clinical efficacy than the initial prescription significant differences. Conclusion: It is feasible to use the orthogonal design and pharmacodynamic validation test to determine the compatibility of compound drugs. The compatibility of the prescription drugs is reasonable.